characterize regulators, drug targets
and similarities among diseases

analyze and integrate
multi-source knowledge
and -omics data

problem

a client asked COSBI to detect the proteins linking different neurodegenerative diseases and identify potential targets for drug repurposing

solution

by developing a custom pipeline of existing tools for public datasets and literature, we computed a quantitative association network of neurodegenerative diseases and inferred disease molecular mechanisms

outcome

a biological interpretation of the results led us to identify a major role of Toll-like receptor pathway in many diseases and some candidate targets

publications

G.I. Allen, N. Amoroso, .. L. Caberlotto, M. Lauria, P. Praveen, C. Priami, .. Alzheimer’s Disease Neuroimaging Initiative. Crowdsourced estimation of cognitive decline and resilience in Alzheimer’s disease. Alzheimer’s & Dementia, Elsevier, 2016.

A. Matone, M. Scott Boyer, J. Carayol, P. Fazelzadeh, G. Lefebvre, A. Valsesia, C. Charon, J. Vervoort, A. Astrup, W. Saris, M. Morine, J. Hager. Network Analysis of Metabolite GWAS Hits: Implication of CPS1 and the Urea Cycle in Weight Maintenance, PLOS ONE, 11(3): e0150495, 2016.

C. Priami and M.J. Morine. analysis of biological systems. Imperial College Press, 2015.

T.-P. Nguyen, C. Priami, L. Caberlotto. Novel Drug Target Identification for the Treatment of Dementia Using Multi-Relational Association Mining. Nat. Sci. Rep., 5:11104, 2015.

T.-P. Nguyen, L. Caberlotto, M.J. Morine, C. Priami. Network Analy- sis of Neurodegenerative Disease Highlights a Role of Toll-like Receptor Signaling. BioMed Research International, 2014.

M.J. Morine, J. Pontes Monteiro, C. Wise, C Teitel, L. Pence, A. Wil- liams, B. Ning, B. McCabe-Sellers, C. Champagne, J. Turner, B. Shelby, M. Bogle, R.D. Beger, C Priami, J. Kaput and the Phillips County Community Partners. Genetic associations with micronutrient levels identified in immune and gastrointestinal networks. Gene and Nutrition, 9, 408, 2014.

P. Lecca, C. Priami. Biological network inference for drug discovery. Drug Discovery Today, 18:5-6, 256-264, 2013

L. Caberlotto, M. Lauria, P. Nguyen, M. Scotti. The central role of AMP-kinase and energy homeostasis impairment in Alzheimer's disease: a multifactor network analysis , PLOS ONE, 8:e78919, 2013.