technical report A formal and integrated framework to simulate evolution of biological pathways


Abstract

We present a formal approach to the study of evolution of biological pathways. The basic idea is to use the Beta Workbench to model and simulate pathway in connection with evolutionary algorithms to implement mutations. A fitness function is used to select individuals at any generation. The feasibility of the approach is demonstrated on the MAPK pathway.



Paper Details

Authors

L. Dematté,  C. Priami,  A. Romanel,  O. Soyer

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/var/papers/TR/TR-13-2007.pdf

Language

English
.