Journal Papers Reduced neuropeptide Y mRNA expression in the prefrontal cortex of subjects with bipolar disorder.


Abstract

Neuroreport. 1999 Jun 3;10(8):1747-50. Reduced neuropeptide Y mRNA expression in the prefrontal cortex of subjects with bipolar disorder. Caberlotto L, Hurd YL. SourceKarolinska Institute, Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden. Abstract In the present study, we compared neuropeptide Y mRNA expression levels in the prefrontal cortex (Brodmann area 9 and 46) of subjects diagnosed with major depression, bipolar disorder and schizophrenia with those in normal controls without a psychiatric history. No correlation was found regarding neuropeptide Y mRNA expression and postmortem interval, age, gender, hemisphere side, suicide as cause of death, or the history of use of substances such as alcohol, marihuana and cocaine/amphetamine. The only significant alteration found was related to the clinical diagnosis; neuropeptide Y mRNA expression was reduced in the group of bipolar subjects as compared to the controls. Overall, the present results confirm an involvement of neuropeptide Y in affective disorders, and show for the first time a specific association between NPY and bipolar disorder.



Paper Details

Authors

L. Caberlotto,  Y. Hurd

Publication

Neuroreport. 1999, 10, , 1747-50

Download

http://www.ncbi.nlm.nih.gov/pubmed/10501568

Language

English
.