Journal Papers The identification and optimisation of novel and selective diamide neuropeptide Y Y2 receptor antagonists


Abstract

A novel small molecule NPY Y2 antagonist (3) identified from high throughput screening is described. A subsequent SAR study and optimisation programme based around this molecule is also described, leading to the identification of potent and soluble pyridyl analogue 36.



Paper Details

Authors

G. Luniss,  A. Barness,  N. Barton,  M. Biagetti,  F. Bianchi,  S. Blowers,  L. Caberlotto,  A. Emmons,  I. Holmes,  D. Montanari,  R. Norris,  D. Walters,  S. Watson

Publication

Bioorg Med Chem Lett. , 19, , 4022-5

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http://www.sciencedirect.com/science/article/pii/S0960894X09008634

Language

English
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