Journal Papers Synthesis and structure-activity relationship of N-(3-azabicyclo[3.1.0]hex-6-ylmethyl)-5-(2-pyridinyl)-1,3-thiazol-2-amines derivatives as NPY Y5 antagonists.


Abstract

A novel class of small molecule NPY Y5 antagonists based around an azabicyclo[3.1.0]hexane scaffold was identified through modification of a screening hit. Structure-activity relationships and efforts undertaken to achieve a favourable pharmacokinetic profile in rat are described.



Paper Details

Authors

M. Biagetti,  C. Leslie,  A. Mazzali,  C. Seri,  D. Pizzi,  J. Bentley,  T. Genski,  R. Di Fabio,  L. Zonzini,  L. Caberlotto

Publication

Bioorg Med Chem Lett. , 20, , 4741-4

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http://www.sciencedirect.com/science/article/pii/S0960894X10009273

Language

English
.