System biology approach sheds light on the effects of caloric restriction and resveratrol on brain aging in mice.


Worldwide population is ageing, and a large part of the growing burden associated with age-related conditions can be prevented or delayed by promoting healthy lifestyle and normalize metabolic risk factors. However, a better understanding of the pleiotropic effects of available nutritional interventions and their influence on the multiple processes affected by aging is needed to select and implement the most promising actions. The influence of nutritional interventions on brain aging is a topic of large interest for its implications in health management and neurodegenerative disease treatment. Here we apply a systems biology approach to gain insights on the effect of two widely used dietary interventions, caloric restriction and resveratrol, on the brain aging process. By combining network analysis and a recently developed transcriptional signature identification method, we expose a number of previously undetected effects including modifications in molecular signaling related to synaptic transmission and glutamatergic pathways involving particularly ionotropic receptor family. The increase sensitivity of our approach, which relies on the use of discriminating signatures to identify significantly affected modules of a protein-protein interaction network, is able to identify molecular functions not classically associated to diet, including histone modifications and neurogenesis.






References

Lacroix S., Lauria M., Scott-Boyer MP., Marchetti L., Priami C., Caberlotto L.. Systems biology approaches to study the molecular effects of caloric restriction and polyphenols on aging processes. Genes Nutr. 2015 Nov;10(6):58. Epub 2015 Nov 25.

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