a partner asked COSBI to determine the pathways involved in adipogenesis under different conditions

network construction
and pathway analysis

identify functional networks affected 
by treatments or phenotypes


by developing a proprietary network-based, functional enrichment algorithm to omics data, we ranked pathways according to their level of involvement at different cellular response time points

proprietary software

COSBI developed a novel network-based, contextual enrichment method




a biological interpretation of the results led us to identify important mechanisms affected by the conditions


C. Priami and M.J. Morine. analysis of biological systems. Imperial College Press, 2015.

L. Marchetti, V.H. Thanh, C. Priami. Simulation algorithms for computational systems biology. In Texts in Theoretical Computer Science. An EATCS Series, Springer, ISBN: 978-3-319-63111-0, 2017.

C. Uluseker, G. Simoni, L. Marchetti, M. Dauriz, A. Matone, C. Priami. A closed-loop multi-level model of glucose homeostasis. PloS ONE, 13 (2): e0190627, 2018.

K. Misselbeck, L. Marchetti, M.S. Field, M. Scotti, C. Priami and P.J. Stover. A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesis. Nat. Sci. Rep., 7:797, 2017.

L. Marchetti, R. Lombardo, C. Priami HSimulator: Hybrid Stochastic/Deterministic Simulation of Biochemical Reaction Networks. Complexity, Article ID 1232868, 2017, doi:10.1155/2017/1232868.

R. Lombardo, C. Priami. Graphical modeling meets systems pharmacology. Gene regulation and systems biology 11, 2017, doi:10.1177/1177625017691937

I. Nassiri, R. Lombardo, M. Lauria, M.J. Morine, P. Moyseos, V. Varma, G.T. Nolen, B. Knox, D. Sloper, J. Kaput and C. Priami. Systems view of adipogenesis via novel omics-driven and tissue-specific activity scoring of network functional modules, Nat. Sci. Rep., 2016.

M. Scott Boyer, S. Lacroix, M. Scotti, M. Morine, J. Kaput, C. Priami. A network analysis of cofactor-protein interactions for analyzing associations between human disease and nutrition, Nat. Sci. Rep., 6:19633, 2016.

T. Nyima, M. Müller, G. Hooiveld, M. Morine, M. Scotti. Nonlinear transcriptomic response to dietary fat intake in the small intestine of C57BL/6J mice, BMC Genomics, 17:106, 2016.

A. Matone, C. O’Grada, E.T. Dillon, C. Morris, M.F. Ryan, M. Walsh, E.R. Gibney, L. Brennan, M.J. Gibney, M.J. Morine, H.M. Roche. Body mass index mediates inflammatory response to acute dietary challenges. Mol Nutr Food Res, 2015.

C. O'Grada, M. Morine, C. Morris, M.F. Ryan, E.T. Dillon, M. Walsh, E. Gibney, L. Brennan, M. Gibney, H. Roche. PBMCs reflect the immune component of the WAT transcriptome - Implications as biomarkers of metabolic health in the postprandial state, Mol Nutr Food Res, 2013.