Systems Biology

We target specialized journals dedicated to the development of computational tools, and broader audience journals where state-of-the art technologies are applied to the investigation and elucidation of biological processes in key and emerging research areas.

The value of our research

publications-infographic

scientific paper November 29, 2024 | npj Systems Biology and Applications

Giampiccolo Stefano, Reali Federico, Fochesato Anna, Iacca Giovanni, Marchetti Luca

Robust parameter estimation and identifiability analysis with hybrid neural ordinary differential equations in computational biology

Abstract: Parameter estimation is one of the central challenges in computational biology. In this paper, we present an approach to estimate model parameters...

Developing a stochastic model of folate-mediated one-carbon metabolism

Develop an accurate mathematical representation of the folate-mediated one-carbon metabolism (FOCM) as an interconnected network of metabolic pathways...

Developing a hierarchical multi-level mathematical model of glucose homeostasis

Develop a comprehensive and structured mathematical representation of the pathophysiologic processes underlying the regulation of glucose homeostasis...

Taking care of immune-beneficial infant gut bacteria

Hunting for foods to help infants build strong immune systems, a New Zealand National Science Challenge. These studies are traditionally conducted trialing...

Our books

Analysis Of Biological Systems

Analysis of Biological Systems collects classical material on analysis, modeling and simulation, thereby acting as a unique point of reference. The joint application of statistical techniques to extract knowledge from big data and map it into mechanistic models is a current challenge of the field, and the reader will learn how to build and use models even if they have no computing or math background. An in-depth analysis of the currently available technologies, and a comparison between them, is also included. Unlike other reference books, this in-depth analysis is extended even to the field of language-based modeling. The overall result is an indispensable, self-contained and systematic approach to a rapidly expanding field of science.

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2015

Simulation Algorithms for Computational Systems Biology

This book explains the state-of-the-art algorithms used to simulate biological dynamics. Each technique is theoretically introduced and applied to a set of modeling cases. Starting from basic simulation algorithms, the book also introduces more advanced techniques that support delays, diffusion in space, or that are based on hybrid simulation strategies. This is a valuable self-contained resource for graduate students and practitioners in computer science, biology and bioinformatics. An appendix covers the mathematical background, and the authors include further reading sections in each chapter.

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2018

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Scientific publications