Systems Pharmacology
From data to actionable knowledge
What we do
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The available biomedical literature and associated data are growing at an unprecedented rate, exceeding the ability of researchers to make effective use of this knowledge-rich amount of information. Through the conduct of numerous projects, COSBI has developed a significant experience in extracting knowledge from multiple sources and frame it into a systems level context
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We capture the wealth of experimental data from the ever-increasing number of technologies and information across multiple layers and integrate them into knowledge-based biological networks to build a systems level view of biological processes, and support the identification of targets and biomarkers
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We combine proprietary and publicly available state-of-the art approaches for the identification of biological signatures allowing the dissection of the biological heterogeneity of a disease, the identification of samples or patients subgroups, as well as the molecular targets underlying the phenotype of interest
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We combine available experimental data on drug, targets, biomarkers, and information across multiple pathways and layers to obtain a system view of physiological and pathological cellular processes and generate mechanistic knowledge that can be employed to develop mathematical models of disease processes
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We develop mathematical models of physiological processes in normal and disease conditions, and Quantitative Systems Pharmacology (QSP) models of increased complexity enabling to predict disease progression or treatment efficacy in several conditions
Partners & Customers
Customer
Amgen
Biotechnology companyCustomer
Vydiant
Biotechnology companyPartner
IEO - Istituto Europeo di Oncologia
Hospital and Research CentreCustomer
UCB Pharma
Pharmaceutical Company