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Systems Pharmacology

Building computational frameworks to support drug discovery and personalized medicine

We combine molecular, cellular, preclinical, and clinical data from different sources to build a systems view of biological processes in healthy and disease condition, setting the basis for mechanistic models and mathematical descriptions of both complex and rare disorders. By integrating preclinical with clinical data, our models enable to identify new targets and biomarkers, simulate disease progression, identify patient subgroups and predict drug efficacy, guiding the advance of small molecules and biological agents through the various phases of their development.

Our focus

Case Studies

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Extracting knowledge from literature to inform Tuberculosis drug and vaccine development

Develop a TB Knowledgebase, that interactively aggregates, organizes, and analyzes publicly available literature and clinical trial documentation to support...

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Investigating the inflammatory signaling characterizing lysosomal storage disorders (LSDs)

Develop a text-mining and systems biology framework to investigate the inflammatory signaling characterizing lysosomal storage disorders (LSDs). First...

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Logical modeling of COVID-19 intracellular infection: supporting therapies development

Develop a logical mathematical model of the intracellular pathways involved in the COVID-19 infection. The model can be used to study several drugs and...

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Predicting the efficacy of trivalent influenza vaccines

Extract a transcriptional biomarker to predict the efficacy of trivalent influenza vaccines and expand our understanding of the early events following...

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Developing a QSP model for prostate cancer immunotherapy

Develop a Quantitative System Pharmacology (QSP) model to evaluate the effect of different immunotherapies in prostate cancer and provide a computational...

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A QSP approach based on a graphical model to improve mRNA vaccine platforms

Analyzing and integrating multi-source knowledge and data, with the goal of clarifying the intricate biological processes involved in the mechanism of...

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