Rejection-based Stochastic Simulation Algorithm (RSSA) is an exact and efficient simulation method for (large-scale) biochemical reactions and tailored for time-consuming propensity function e.g. Michaelis-Menten kinetics.

  • dRSSA supports biochemical reactions with delays.
  • sRSSA is able to generate multiple trajectories simultaneously in one simulation run.
  • tRSSA supports biochemical reactions with time-dependent rates.



V. H. Thanh, C. Priami and R. Zunino. Efficient Rejection-based Simulation of Biochemical Reactions with Stochastic Noise and Delays, J. Chem. Phys., 141(13):134116, 2014. link

V. H. Thanh, R. Zunino and C. Priami. On the Rejection-based Algorithm for Simulation and Analysis of Large-Scaled Reaction Networks, J. Chem. Phys., 142(24):244106, 2015. link

V. H. Thanh and C. Priami. Simulation of Biochemical Reactions with Time-Dependent Rates by the Rejection-based Algorithm. J. Chem. Phys., 143(5): 054104, 2015. link