Objectives
Develop a parsimonious model of aggrephagy in ALS that can be incorporated as a selective autophagy module within published mTOR QSP models. In this study, we aim to:
• identify and model a mechanistic link between aggrephagy and the mTOR pathway;
• provide a plausible literature-based parameterization and calibration strategy;
• characterize the model’s qualitative dynamical behavior.
Digital copies of selected posters are available upon request at info@cosbi.eu.