Motivation and Background
- Virtual populations (VPops) represent uncertainty and inter-
individual phenotypic variability in QSP models, supporting clinical
decision-making [1]
- Widely used approaches following Allen et al. [2] generate large
plausible populations (PPops) and select VPops to match target
clinical distributions
- Such methods are typically evaluated on single models,
assuming transferability
- As QSP model complexity increases, PPop generation becomes a
major computational bottleneck
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