A multiscale physiologically based pharmacokinetic model to support mRNA-encoded BiTE therapy in cancer treatment

Category
Publications
Author
Giada Fiandaca, Elio Campanile, Lorena Leonardelli, Elisa Pettinà, Stefano Giampiccolo, Lorenzo Dasti, Natascia Zangani, Luca Marchetti
Pub. date
July 1, 2025

Published in Molecular Therapy: Nucleic Acids

A new publication in Molecular Therapy: Nucleic Acids presents a multi-scale PBPK model that simulates the journey of in vivo–expressed bispecific T-cell engagers (BiTEs)—from mRNA delivery to tumor targeting—enabling better prediction of therapeutic exposure and efficacy.

This model supports patient-specific dosing, improved safety predictions, and more efficient translation of mRNA-based immunotherapies into clinical practice.

Congratulations to the authors from COSBI: Elio Campanile, Lorena Leonardelli, Elisa Pettinà, Stefano Giampiccolo, and the authors from the University of Trento: Giada Fiandaca, Lorenzo Dasti, Natascia Zangani, Luca Marchetti for their successful multidisciplinary contribution, along with the collaboration of Elizabeth J. Carstens from the Dana-Farber Cancer Institute.

Read the full article here.

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