Published in Molecular Therapy: Nucleic Acids
A new publication in Molecular Therapy: Nucleic Acids presents a multi-scale PBPK model that simulates the journey of in vivo–expressed bispecific T-cell engagers (BiTEs)—from mRNA delivery to tumor targeting—enabling better prediction of therapeutic exposure and efficacy.
This model supports patient-specific dosing, improved safety predictions, and more efficient translation of mRNA-based immunotherapies into clinical practice.
Congratulations to the authors from COSBI: Elio Campanile, Lorena Leonardelli, Elisa Pettinà, Stefano Giampiccolo, and the authors from the University of Trento: Giada Fiandaca, Lorenzo Dasti, Natascia Zangani, Luca Marchetti for their successful multidisciplinary contribution, along with the collaboration of Elizabeth J. Carstens from the Dana-Farber Cancer Institute.
Read the full article here.
