New strategies to target quorum sensing in bacteria
We are glad to share a new publication co-authored by COSBI researchers Chiara Cimolato (who spent a few months at COSBI working on this), Luca Marchetti, and Gianluca Selvaggio, together with colleagues from Università degli Studi di Padova and Università di Trento.
The study focuses on “quorum quenching” strategies aimed at inhibiting quorum sensing—the cell-density-dependent mechanism bacteria use to communicate and spread antimicrobial resistance.
The work provides a comprehensive mathematical analysis of two quorum sensing architectures, comparing their dynamic behavior and highlighting key features such as bistability and hysteresis. Building on this foundation, the authors evaluate four distinct quorum quenching strategies — signal molecule degradation, pharmaceutical inhibition, CRISPR interference, and RNA interference — offering a systems-level perspective on how to disrupt pathogenic communication.
This research contributes to the rational design of synthetic biology interventions and next-generation antimicrobial therapies.
Read the full paper here
#COSBI #Research #QuorumSensing #QuorumQuenching #AntimicrobialResistance #SyntheticBiology #MathematicalModels
