A joint research project to unravel the fundamental signaling processes connected to cancer progression
The project with Istituto Europeo di Oncologia will promote the development of a comprehensive mathematical model of the activation, internalization, and trafficking of the epidermal growth factor receptor (EGFR): a key signaling molecule involved in fundamental physiological processes (e.g., proliferation, differentiation) and in cancer (e.g., tumor growth, cell migration/invasion). The ultimate goal is to obtain an in silico tool to test hypotheses and generate novel and non-obvious predictions on the regulation of EGFR signaling that could be relevant to cancers harboring a deregulated EGFR pathway.
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