Elisa Pettinà presents COSBI research at BIOMATH 2025
Elisa Pettinà, PhD student at COSBI, participated in the BIOMATH 2025 international conference (15-20 June), held in Sofia and organized by the Bulgarian Academy of Sciences.
She contributed to the Special Topic session “Mathematical Models of the Immune System in Human Disease” with a talk entitled:
“A Multiscale PBPK Model for Predicting the Trafficking of mRNA-encoded Therapeutics in Mice”
The presentation focused on a physiologically based pharmacokinetic (PBPK) model that integrates multiple biological scales to simulate the distribution of mRNA-based therapies in mice. The work aims to support translational research by enhancing the predictive understanding of how these therapeutics behave in vivo.
This research builds on COSBI’s ongoing efforts in computational modeling to support the development of mRNA-based therapeutics. Elisa also contributed to a recent study published in Molecular Therapy – Nucleic Acids (Fiandaca et al., 2025), which describes a multi-scale PBPK model designed to predict the biodistribution of both recombinant and mRNA-encoded bispecific T-cell engagers (BiTEs) for cancer therapy. The model enables in silico exploration of drug delivery strategies, aiming to improve the personalization and efficiency of mRNA treatments.
Her participation in BIOMATH 2025 offered the opportunity to share this line of work with the broader modeling community and to engage in scientific exchange at the intersection of mathematics, immunology, and translational medicine.
The abstract of Elisa’s presentation is available here.
