Poster at QSPC 2026
At QSPC 2026, COSBI also contributed to advancing computational approaches for the development of mRNA-based therapies, an area of growing relevance in biomedical research and drug development.
During the poster session, Elisa Pettinà and Luca Marchetti presented a multiscale computational platform integrating quantitative systems pharmacology (QSP) and physiologically based pharmacokinetic (PBPK) modeling. This framework is designed to support the development and optimization of both mRNA vaccines and mRNA-encoded therapeutics.
The platform captures the full cascade of biological processes underlying mRNA-based interventions, from delivery and intracellular trafficking to protein translation and systemic distribution. By combining mechanistic detail across multiple biological scales, it enables a more comprehensive understanding of how formulation, cellular processing, and physiological factors interact to determine therapeutic outcomes.
Such integrative approaches are particularly valuable for improving translational insights, supporting cross-species analysis, and guiding the optimization of dosing strategies and treatment design.
This work contributes to ongoing efforts to develop robust computational tools that can better support the complexity of emerging therapeutic modalities.
