Publications

We target specialized journals dedicated to the development of computational tools, and broader audience journals where state-of-the art technologies are applied to the investigation and elucidation of biological processes in key and emerging research areas.

The value of our research

publications-infographic

poster June 9, 2026 | PAGE 2026 - Dubrovnik

Chiesa Martina, Righetti Elena, Domenici Enrico, Reali Federico

Toward a Quantitative Systems Pharmacology framework of cell-level alpha-synuclein dynamics

Introduction: Parkinson’s disease (PD) – the second most prevalent neurodegenerative disorder worldwide [1] – is characterized by the progressive...

scientific paper May 27, 2026 | npj Systems Biology and Applications

Giampiccolo Stefano, Iacca Giovanni, Marchetti Luca

A novel approach to quantify out-of-distribution uncertainty in Neural and Universal Differential Equations

Abstract: Dynamical systems play a central role across the quantitative sciences, offering a powerful mathematical framework to describe, analyze, and...

poster April 8, 2026 | QSPC 2026 - Leiden

Righetti Elena, D’Agaro Niccolò, Bozza Marco, Simone Pezzuto, Reali Federico

No One-Size-Fits-All: A Multi-Model Evaluation of Optimization-Based and Surrogate-Assisted Virtual Population Generation in QSP

Motivation and Background: Virtual populations (VPops) represent uncertainty and inter- individual phenotypic variability in QSP models, supporting...

scientific paper April 7, 2026 | The AAPS Journal

Tomasoni Danilo, Paris Alessio, Visintainer Roberto, Cook Kevin, Chen Aochiu, Figueroa Isabel, Thomas Veena, Marchetti Luca

Predicting Aberrant Fc-fusion Protein Pharmacokinetics from In Silico Structural Properties and Physiologically Based Pharmacokinetic (PBPK) Modeling

The fusion of therapeutic proteins to the Fc domain of monoclonal antibodies (mAbs) generally improves the proteins' pharmacokinetic (PK) characteristics...

scientific paper December 23, 2025 | bioRxiv

Campanile Elio, Pettinà Elisa, Giampiccolo Stefano, Leonardelli Lorena, Marchetti Luca

Physiologically Based Pharmacokinetic Modeling of mRNA-Encoded Therapeutics: A Multiscale Framework for LNP and Antibody Trafficking in Mice.

Antibody-based therapeutics have revolutionized disease treatment, and recent advances in messenger RNA (mRNA) technologies have opened new opportunities...

scientific paper June 16, 2025 | Molecular Therapy Nucleic Acids

Fiandaca Giada, Campanile Elio, Leonardelli Lorena, Pettinà Elisa, Giampiccolo Stefano, Carstens Elizabeth J., Dasti Lorenzo, Zangani Natascia, Marchetti Luca

A multiscale physiologically based pharmacokinetic model to support mRNA-encoded BiTE therapy in cancer treatment

In the field of cancer therapy, bispecific T cell engagers (BiTEs) have demonstrated significant potential. However, their clinical application is constrained...

Our books

Analysis Of Biological Systems

Analysis of Biological Systems collects classical material on analysis, modeling and simulation, thereby acting as a unique point of reference. The joint application of statistical techniques to extract knowledge from big data and map it into mechanistic models is a current challenge of the field, and the reader will learn how to build and use models even if they have no computing or math background. An in-depth analysis of the currently available technologies, and a comparison between them, is also included. Unlike other reference books, this in-depth analysis is extended even to the field of language-based modeling. The overall result is an indispensable, self-contained and systematic approach to a rapidly expanding field of science.

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2015

Simulation Algorithms for Computational Systems Biology

This book explains the state-of-the-art algorithms used to simulate biological dynamics. Each technique is theoretically introduced and applied to a set of modeling cases. Starting from basic simulation algorithms, the book also introduces more advanced techniques that support delays, diffusion in space, or that are based on hybrid simulation strategies. This is a valuable self-contained resource for graduate students and practitioners in computer science, biology and bioinformatics. An appendix covers the mathematical background, and the authors include further reading sections in each chapter.

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2018

Check out COSBI publications on PubMed

Scientific publications