Publications

We target specialized journals dedicated to the development of computational tools, and broader audience journals where state-of-the art technologies are applied to the investigation and elucidation of biological processes in key and emerging research areas.

The value of our research

publications-infographic

scientific paper November 29, 2024 | npj Systems Biology and Applications

Stefano Giampiccolo, Federico Reali, Anna Fochesato, Giovanni Iacca, Luca Marchetti

Robust parameter estimation and identifiability analysis with hybrid neural ordinary differential equations in computational biology

Parameter estimation is one of the central challenges in computational biology. In this paper, we present an approach to estimate model parameters and...

January 29, 2024

Strengths and limitations of non-disclosive data analysis: a comparison of breast cancer survival classifiers using VisualSHIELD

Preserving data privacy is an important concern in the research use of patient data. The DataSHIELD suite enables privacy-aware advanced statistical analysis...

January 24, 2024

A minimal PBPK model to accelerate preclinical development of drugs against tuberculosis

Understanding drug exposure at disease target sites is pivotal to profiling new drug candidates in terms of tolerability and efficacy. Such quantification...

July 14, 2023

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization

Differentiation is critical for cell fate decisions, but the signals involved remain unclear. The kidney proximal tubule (PT) cells reabsorb disulphide...

January 5, 2023

Single-cell-led drug repurposing for Alzheimer’s disease

Alzheimer's disease is the most common form of dementia. Notwithstanding the huge investments in drug development, only one disease-modifying treatment...

December 22, 2021

High-Precision Biomedical Relation Extraction for Reducing Human Curation Efforts in Industrial Applications

Despite the great progress in the techniques, the retrieved evidence still needs to undergo a time-consuming manual curation process to be truly useful...

Our books

Analysis Of Biological Systems

Analysis of Biological Systems collects classical material on analysis, modeling and simulation, thereby acting as a unique point of reference. The joint application of statistical techniques to extract knowledge from big data and map it into mechanistic models is a current challenge of the field, and the reader will learn how to build and use models even if they have no computing or math background. An in-depth analysis of the currently available technologies, and a comparison between them, is also included. Unlike other reference books, this in-depth analysis is extended even to the field of language-based modeling. The overall result is an indispensable, self-contained and systematic approach to a rapidly expanding field of science.

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2015

Simulation Algorithms for Computational Systems Biology

This book explains the state-of-the-art algorithms used to simulate biological dynamics. Each technique is theoretically introduced and applied to a set of modeling cases. Starting from basic simulation algorithms, the book also introduces more advanced techniques that support delays, diffusion in space, or that are based on hybrid simulation strategies. This is a valuable self-contained resource for graduate students and practitioners in computer science, biology and bioinformatics. An appendix covers the mathematical background, and the authors include further reading sections in each chapter.

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2018

Check out COSBI publications on PubMed

Scientific publications